Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination.

@article{Sleijffers2003CytokinePP,
  title={Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination.},
  author={Annemarie Sleijffers and Berran Yucesoy and Michael L. Kashon and Johan Garssen and Frank R de Gruijl and Greet J. Boland and Jan van Hattum and Michael I. Luster and Henk van Loveren},
  journal={Journal of immunology},
  year={2003},
  volume={170 6},
  pages={3423-8}
}
UVB exposure can alter immune responses in experimental animals and humans. In an earlier human volunteer study, we demonstrated that hepatitis B-specific humoral and cellular immunity after vaccination on average were not significantly affected by UVB exposure. However, it is known that individuals differ in their susceptibility to UVB-induced immunomodulation, and it was hypothesized that polymorphisms in specific cytokines may play a role in this susceptibility. In this respect, we… CONTINUE READING
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