Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility.

@article{Ohman2009CytokinePA,
  title={Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility.},
  author={Hanna Ohman and Aila Tiitinen and Mervi Halttunen and Matti Lehtinen and Jorma Paavonen and H-M Surcel},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={199 9},
  pages={1353-9}
}
Chronic inflammation induced by Chlamydia trachomatis can lead to tubal factor infertility (TFI). To investigate the genetic basis of chlamydial TFI and various manifestations of tubal damage, we studied functional polymorphisms in selected cytokine genes (IL-10 -1082 A/G, -819 T/C, and -592 A/C; IFN-gamma +874 T/A; TNF-alpha -308 G/A; TGF-beta1 codons 10 T/C and 25 G/C; and IL-6 -174 G/C) in 114 women with laparoscopically verified TFI (hereafter known as "cases") and in 176 controls. Evidence… CONTINUE READING

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