Cytokine patterns and viral load in lymph nodes during the early stages of SIV infection.

@article{Khatissian1996CytokinePA,
  title={Cytokine patterns and viral load in lymph nodes during the early stages of SIV infection.},
  author={Emmanuel Khatissian and Lisa Chakrabarti and Bruno Hurtrel},
  journal={Research in virology},
  year={1996},
  volume={147 2-3},
  pages={181-9}
}
To elucidate the initial pathogenic events in lymphoid organs, the major reservoir of virus in HIV infection, follow-up of viral load and cytokine mRNA production was performed in the rhesus macaque SIV mac251 model. In the first experiment, lymph nodes (LN) obtained from animals sacrificed at early time points following intravenous (i.v.) inoculation with a high viral dose, showed that the production of cytokine mRNA in LN (IFN gamma, IL1 beta, IL2, IL4, IL12p40, IL6, IL10, TNF alpha and TNF… CONTINUE READING

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