Cytokine networks in the regulation of inflammation and fibrosis in the lung.

@article{Elias1990CytokineNI,
  title={Cytokine networks in the regulation of inflammation and fibrosis in the lung.},
  author={Jack A Elias and Bruce Freundlich and Jeffery A. Kern and Joel Rosenbloom},
  journal={Chest},
  year={1990},
  volume={97 6},
  pages={1439-45}
}
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6-production. These studies demonstrated the existence of complex cytokine networks by which inflammatory cells regulate fibroblast function and fibroblasts, in turn, feed back to… CONTINUE READING
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