Cytokine networks in solid human tumors: regulation of angiogenesis.

  title={Cytokine networks in solid human tumors: regulation of angiogenesis.},
  author={R. Leek and Adrian L. Harris and Claire E. Lewis},
  journal={Journal of leukocyte biology},
  volume={56 4},
The isolation, purification, and molecular cloning of an increasing number of cytokines and their receptors have allowed major advances in our understanding of the relevance of these proteins to the pathobiology and treatment of such human diseases as neoplasia. Cytokines produced by the multiple cell types present within the microenvironment of solid tumors from a complex, dynamic network, in which they have overlapping properties, induce other cytokines and alter the expression of soluble and… CONTINUE READING

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