Cytokine network in rectal mucosa in perianal Crohn's disease: relations with inflammatory parameters and need for surgery.

@article{Ruffolo2008CytokineNI,
  title={Cytokine network in rectal mucosa in perianal Crohn's disease: relations with inflammatory parameters and need for surgery.},
  author={Cesare Ruffolo and Melania Scarpa and Diego Faggian and Anna da Pozza and Filippo Navaglia and Renata D'inc{\'a} and Pranvera Hoxha and Giovanna Romanato and Lino Polese and Giacomo carlo Sturniolo and Mario Plebani and Davide F D'amico and Imerio Angriman},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 10},
  pages={
          1406-12
        }
}
BACKGROUND Nowadays anti-TNF-alpha antibodies are used for the treatment of perianal Crohn's disease (CD). Nevertheless, this treatment is effective in only a part of these patients and recent studies suggested a role for other cytokines in chronic bowel inflammation. The aim of this study was to assess the cytokine profile in the rectal mucosa of patients affected by perianal CD and to understand its relations with the systemic cytokine profile and inflammatory parameters and the need for… CONTINUE READING
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