Cytokine modulation alters pulmonary clearance of Rhodococcus equi and development of granulomatous pneumonia.

Abstract

Rhodococcus equi, a facultative intracellular bacterium, causes chronic, often fatal granulomatous pneumonia in young horses and in humans with AIDS. The inability of host alveolar macrophages to kill intracellular R. equi results in the development of granulomas and progressive loss of pulmonary parenchyma. Clearance of the organism from the lung requires… (More)

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