Cytokine-modulated regulation of helper T cell populations.

  title={Cytokine-modulated regulation of helper T cell populations.},
  author={Andrew J Yates and Carina Bergmann and J. Leo van Hemmen and Jaroslav Stark and Robin Callard},
  journal={Journal of theoretical biology},
  volume={206 4},
Helper T (Th) cells are a crucial component of the adaptive immune system and are of fundamental importance in orchestrating the appropriate response to pathogenic challenge. They fall into two broad categories defined by the cytokines each produces. Th1 cells produce interferon- gamma and are required for effective immunity to intracellular bacteria, viruses and protozoa whereas Th2 produce IL-4 and are required for optimal antibody production to T-dependent antigens. A great deal of… CONTINUE READING