Cytokine-modified VSV is attenuated for neural pathology, but is both highly immunogenic and oncolytic.

@article{Miller2009CytokinemodifiedVI,
  title={Cytokine-modified VSV is attenuated for neural pathology, but is both highly immunogenic and oncolytic.},
  author={James M. Miller and Sarah McNulty Bidula and Troels Mygind Jensen and Carol Shoshkes Reiss},
  journal={International journal of interferon, cytokine and mediator research},
  year={2009},
  volume={1},
  pages={15-32}
}
Vesicular stomatitis virus (VSV), an enveloped, nonsegmented, negative-stranded RNA virus, is being tested by several laboratories as an antitumor agent. Unfortunately, viral infection of the central nervous system (CNS) has been observed by many groups following administration to tumor-bearing animals. In rodents, VSV encephalitis is characterized by weight-loss, paralysis, and high mortality. In order to provide protection from VSV infection of the CNS after therapeutic administration, we… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 100 references

Recombinant vesicular stomatitis viruses from DNA.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 11 Excerpts
Highly Influenced

YAC-1 variant clones selected for resistance to natural killer cytotoxic factors are also resistant to natural killer cell-mediated cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America • 1983
View 3 Excerpts
Highly Influenced

RNA viruses: host gene responses to infections

CS Reiss
Hackensack, NJ: World Scientific, • 2009

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