Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.

@article{Opdenakker1991CytokinemediatedRO,
  title={Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.},
  author={Ghislain Opdenakker and Stefan Masure and Bernard Grillet and Jo Van Damme},
  journal={Lymphokine and cytokine research},
  year={1991},
  volume={10 4},
  pages={317-24}
}
Gelatinases (type IV collagenases) produced by normal peripheral blood leukocytes were studied by the use of a substrate conversion assay. When monocytes were stimulated with IL-1 beta discrete amounts of a 85-kDa gelatinase were detected. This type of gelatinase comigrated with a phorbol ester-inducible metalloproteinase from human tumor cells. The levels of induction of the monocytic enzyme after stimulation with IL-1, double-stranded RNA, LPS, and mitogens paralleled those of the secondary… CONTINUE READING