Cytokine-mediated regulation of granulocyte colony-stimulating factor production.

  title={Cytokine-mediated regulation of granulocyte colony-stimulating factor production.},
  author={Matthew D. Hannen and Ursula Banning and Halvard Boenig and Y M Kim and Dong Ill Shin and Ioana Lorenz and K. H. Seeger and Dieter Koerholz},
  journal={Scandinavian journal of immunology},
  volume={50 5},
Granulocyte colony-stimulating factor (G-CSF) is an important regulator of granulopoiesis and an inducer of T helper 2 (Th2)-related cytokines. In this study we investigated the mechanism of cytokine-modulated G-CSF production in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMC) and bone marrow stromal cells (BMSC). In PBMC, LPS significantly induced G-CSF and interleukin (IL)-1, an inducer of G-CSF. Both were partly inhibited by IL-4, IL-6 and IL-10. None of these… CONTINUE READING