Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells

@article{Whetton1994CytokinemediatedPK,
  title={Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells},
  author={Anthony D. Whetton and Clare M. Heyworth and Sian E. Nicholls and Caroline A Evans and Janet M. Lord and T. Michael Dexter and P. Jane Owen-Lynch},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={125},
  pages={651 - 659}
}
Granulocyte macrophage colony-forming cells (GM-CFC) have the potential to develop into either macrophages and/or neutrophils. With a highly enriched population of these cells we have found that although GM-CFC are equally responsive to macrophage colony stimulating factor (M-CSF) and stem cell factor (SCF) in terms of DNA synthesis, M-CSF stimulated the development of colonies containing macrophages in soft gel assays, while SCF promoted neutrophilic colony formation. When SCF and M-CSF were… CONTINUE READING

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Protein kinase C activators can interact synergistically with G - CSF or IL - 6 to stimulate colony formation from enriched granulocyte macrophage colony , . forming cells

  • K. Imamura, A. Diaaoux
  • Blood .
  • 1993

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