Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation.

@article{Arstall1999CytokinemediatedAI,
  title={Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation.},
  author={Margaret Arstall and Douglas Brian Sawyer and Ryuji Fukazawa and Ralph A. Kelly},
  journal={Circulation research},
  year={1999},
  volume={85 9},
  pages={
          829-40
        }
}
Increased production of nitric oxide (NO) after induction of the cytokine-inducible isoform of nitric oxide synthase (iNOS or NOS2) in cardiac myocytes and other parenchymal cells within the heart may in addition to contributing to myocyte contractile dysfunction also contribute to the induction of programmed cell death (apoptosis). To investigate the mechanism(s) by which increased NO production leads to apoptosis, we examined the role of NO in primary cultures of neonatal rat ventricular… CONTINUE READING

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