Cytokine manipulation in animal models of asthma.

  title={Cytokine manipulation in animal models of asthma.},
  author={Romain A. Pauwels and Guy Brusselle and Johan C. Kips},
  journal={American journal of respiratory and critical care medicine},
  volume={156 4 Pt 2},
We have developed in C57 Black 6 mice an in vivo model of allergic airway inflammation characterized by the presence of IgE antibodies to an inhaled antigen, peribronchial infiltrates with an increased number of eosinophils, and an increased airway responsiveness to nonantigenic bronchoconstrictor stimuli. In this animal model we have investigated the role of different cytokines in the development of IgE antibodies to inhaled antigen, eosinophilic airway inflammation, and airway… CONTINUE READING
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