Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation.

@article{Autenrieth1997CytokineME,
  title={Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation.},
  author={I. Autenrieth and N Bucheler and Erwin Bohn and Georg Heinze and Ivan Horak},
  journal={Gut},
  year={1997},
  volume={41 6},
  pages={793-800}
}
BACKGROUND Mice deficient in interleukin-2 (IL-2) develop inflammatory bowel disease resembling ulcerative colitis in humans. Recent studies provided evidence that alpha beta T cells, particularly CD4 T cells, rather than B cells, are involved in the pathogenesis of bowel inflammation of IL-2 deficient mice. AIM To analyse the pattern of expression of cytokine mRNA in intestinal tissue of normal and IL-2 deficient mice. METHODS Expression of beta-actin, IL-1 alpha, IL-1 beta, IL-6, IL-10… CONTINUE READING