Cytokine involvement in cancer anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate on cytokine downregulation and improvement of clinical symptoms.

@article{Mantovani1998CytokineII,
  title={Cytokine involvement in cancer anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate on cytokine downregulation and improvement of clinical symptoms.},
  author={Giovanni Mantovani and Antonio Macci{\`o} and Paola Lai and E. Rabino Massa and Massimo Ghiani and Maria Cristina Santona},
  journal={Critical reviews in oncogenesis},
  year={1998},
  volume={9 2},
  pages={99-106}
}
The characteristic clinical picture of anorexia, tissue wasting, loss of body weight accompanied by a decrease in muscle mass and adipose tissue, and poor performance status that often precedes death has been named the cancer-related anorexia/cachexia syndrome (CACS). Chronic administration of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) either alone or in combination, is capable of reproducing the different features of CACS… CONTINUE READING

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