Cytokine-induced sickness behavior

  title={Cytokine-induced sickness behavior},
  author={K. Kelley and R. Bluth{\'e} and R. Dantzer and J. Zhou and S. Broussard},
  journal={Brain, Behavior, and Immunity},
  • K. Kelley, R. Bluthé, +2 authors S. Broussard
  • Published 2003
  • Psychology, Medicine
  • Brain, Behavior, and Immunity
  • The behavioral repertoire of humans and animals changes dramatically following infection. Sick individuals have little motivation to eat, are listless, complain of fatigue and malaise, loose interest in social activities and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain and fail to concentrate. Proinflammatory cytokines acting in the brain cause sickness behaviors. These nearly universal behavioral changes are a… CONTINUE READING

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