Cytokine-induced sickness behavior

  title={Cytokine-induced sickness behavior},
  author={Keith W. Kelley and Rose Marie Bluth{\'e} and Robert Dantzer and Jian-hua Zhou and Wen Hong Shen and Rodney W. Johnson and Suzanne Rene Broussard},
  journal={Brain, Behavior, and Immunity},
Cytokine-Induced Sickness Behavior and Depression
Current evidence that favors the view that acute inflammation induces sickness behavior whereas chronic inflammation can lead to depressive-like behaviors that are mediated by IDO is discussed.
Twenty years of research on cytokine-induced sickness behavior
Proinflammatory cytokines and sickness behavior: implications for depression and cancer-related symptoms.
  • J. Myers
  • Medicine, Biology
    Oncology nursing forum
  • 2008
Sickness behavior resulting from cytokine release may provide a framework to explain many cancer-related symptoms, including depression, cognitive impairment, cachexia, fatigue, and a component of pain perception.
CBSM effects on sickness behavior and pro -inflammatory cytokine mechanisms in breast cancer survivors
This study provides the first attempt to develop a standardized measure to assess sickness behavior using standard self-report questionnaires commonly used with cancer patients and shows high internal consistency, adequate test-retest reliability, and good convergent validity with both psychological and biological correlates.
Social context modulates sickness behavior
Zebra finches kept in isolation markedly reduced activity, but those kept in a colony setting did not, and birds in a social context were able to overcome the behavioral, but not physiological, symptoms usually associated with an inflammatory response.
Measuring sickness behavior in the context of pancreatic cancer.
Sickness Behavior in Community-Dwelling Elderly
The results imply that some aspects of the symptom panorama in elderly individuals with impaired cardiac function or heart failure could represent sickness behavior, and inflammation mediates the relationship between impaired heart function and a symptom cluster including anhedonia, fatigue, and sleepiness.
Infection-induced proin X ammatory cytokines are associated with decreases in positive a V ect , but not increases in negative a V ect
Infection commonly triggers nonspeciWc psychological and behavioral changes including fatigue and malaise, anhedonia, inability to concentrate, and disturbed sleep that collectively are termed
Mouse testing methods in psychoneuroimmunology: an overview of how to measure sickness, depressive/anxietal, cognitive, and physical activity behaviors.
Provided is a detailed overview of behavioral tests frequently used to examine neuroimmune activation in mice with a special emphasis on preexperimental conditions that can confound or prevent successful immunobehavioral experimentation.


Cytokine-Induced Sickness Behavior: Where Do We Stand?
  • R. Dantzer
  • Biology
    Brain, Behavior, and Immunity
  • 2001
There is clinical and experimental evidence that activation of the brain cytokine system is associated with depression, although the exact relationship between sickness behavior and depression is still elusive.
Behavioral aspects of experimental autoimmune encephalomyelitis
Endotoxin produces a depressive-like episode in rats
Sickness behavior as a new target for drug development.
The pain of being sick: implications of immune-to-brain communication for understanding pain.
Evidence is reviewed supporting the idea that proinflammatory cytokines exert powerful pain facilitatory effects following their release in the body, in the brain, and in the spinal cord.
Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.
The results suggest that the receptor mechanisms that mediate the behavioral and pyrogenic effects of IL-1 are heterogeneous, similar to other cytokines released during immune activation.
Cytokine-induced sickness behaviour: mechanisms and implications
Characterization of cytokine-induced hyperalgesia
Stress and immunity: an integrated view of relationships between the brain and the immune system.