Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line.

@article{Ohta1990CytokineinducedRO,
  title={Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line.},
  author={Ken Ohta and Yukio Hirata and Taihei Imai and Katsue Kanno and Tetsuro Emori and Masayoshi Shichiri and Fumiaki Marumo},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={169 2},
  pages={578-84}
}
To elucidate the mechanism by which endothelin-1 (ET-1) is released from renal epithelial cells, we have investigated the effects of several compounds on release of ET-1-like immunoreactivity (LI) from LLCPK1 cell line. Thrombin, transforming growth factor-beta, cytokines (tumor necrotizing factor-alpha, interleukin-1 beta), and phorbol ester stimulated ET-1-LI release in a time- and dose-dependent manner. The cytokine-induced ET-1-LI release was not affected by indomethacin. Northern blot… CONTINUE READING