Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes.

@article{Zhang2001CytokineinducedPA,
  title={Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes.},
  author={Quanshun Zhang and David Audoen Maddock and J P Chen and Stephan Heo and C Chiu and Dongmei Lai and K Souza and Sameet Mehta and Yinsheng Wan},
  journal={International journal of oncology},
  year={2001},
  volume={19 5},
  pages={
          1057-61
        }
}
A previous study has shown that UV activates the PI3K/AKT cell survival pathway while inducing cell death in human skin in vivo and cultured human keratinocytes in vitro, and yet the upstream pathway leading to the activation of AKT has not been thoroughly investigated. In this study we found that UV-induced phosphorylation of p38 and AKT in a time-dependent manner. The phosphorylation of p38 started at 5 min post UV irradiation, peaked at about 30 min, and remained elevated up to 2 h. The… CONTINUE READING

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