Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts.

Abstract

The mechanism responsible for cardiac depression in septic shock remains unknown. The present study examined whether nitric oxide (NO) overproduced by inducible NO synthase (iNOS) can inhibit aerobic energy metabolism and impair the myocardial function in endotoxin-treated rat hearts. Lipopolysaccharide (LPS) significantly decreased systolic blood pressure… (More)

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@article{Tatsumi2004CytokineinducedNO, title={Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts.}, author={Tetsuya Tatsumi and Kazuko Akashi and Natsuya Keira and Satoaki Matoba and Akiko Mano and Jun Shiraishi and Satoshi Yamanaka and Miyuki Kobara and Nobuhiro Hibino and Satoru Hosokawa and Jun Asayama and Shinji Fushiki and Henry Fliss and Masao Nakagawa and Hiroaki Matsubara}, journal={Journal of molecular and cellular cardiology}, year={2004}, volume={37 3}, pages={775-84} }