Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors.

@article{Mesiano2012CytokineinducedK,
  title={Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors.},
  author={Giulia Mesiano and Maja Todorovic and Loretta Gammaitoni and Valeria Leuci and Lidia Giraudo Diego and Fabrizio Carnevale-Schianca and Franca Fagioli and Wanda Piacibello and Massimo Aglietta and Dario Sangiolo},
  journal={Expert opinion on biological therapy},
  year={2012},
  volume={12 6},
  pages={673-84}
}
INTRODUCTION Cytokine-induced killer (CIK) cells are heterogeneous ex vivo-expanded T lymphocytes with mixed T-NK phenotype and endowed with a wide MHC-unrestricted antitumor activity. CIK cells can be expanded from peripheral blood mononuclear cells (PBMC) cultured with the timed addition of IFN-γ, Ab anti-CD3 and IL2. A consistent subset of mature CIK cells presents a CD3(+)CD56(+) phenotype. The CD3(+)CD56(+) cellular subset is the main responsible for the tumor-killing activity, mostly… CONTINUE READING
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