Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.

Abstract

OBJECTIVE To compare the regulation of aggrecanase messenger RNA (mRNA) and enzyme activity by proinflammatory cytokines in primary mouse chondrocytes. METHODS Primary chondrocytes were isolated from knee epiphyses of 6-8-day-old mice and cultured as monolayers. The cells were incubated with tumor necrosis factor α (TNFα), oncostatin M (OSM), or… (More)
DOI: 10.1002/art.27661

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@article{Rogerson2010CytokineinducedII, title={Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.}, author={Fraser M. Rogerson and Yuen Ming Chung and Michael E Deutscher and Karena Last and Amanda J Fosang}, journal={Arthritis and rheumatism}, year={2010}, volume={62 11}, pages={3365-73} }