Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats.

  title={Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats.},
  author={Carlos Plata-Salam{\'a}n and Elizabeth Peloso and Evelyn Satinoff},
  journal={The American journal of physiology},
  volume={275 4 Pt 2},
In earlier work, we reported that genetically obese (fa/fa) Zucker rats exhibited significantly greater anorexia than did lean (Fa/Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1beta. Here, we investigated the fever response of obese (fa/fa) and lean (Fa/Fa) Zucker rats to intracerebroventricular microinfusion of IL-1beta as well as to the following other cytokines: IL-2, IL-6, and tumor necrosis factor-alpha (TNF-alpha). Core body temperature was monitored by a… CONTINUE READING

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