Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

  title={Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.},
  author={Thomas M. Folks and J. Shawn Justement and Audrey L. Kinter and Charles A Dinarello and Anthony S. Fauci},
  volume={238 4828},
A model system for cytokine-induced up-regulation of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected promonocyte clones was established. The parent promonocyte cell line U937 was chronically infected with HIV-1 and from this line a clone, U1, was derived. U1 showed minimal constitutive expression of HIV-1, but virus expression was markedly up-regulated by a phytohemagglutinin-induced supernatant containing multiple cytokines and by recombinant granulocyte… CONTINUE READING
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