Cytokine-induced cytokine production by conventional and innate lymphoid cells.

@article{Guo2012CytokineinducedCP,
  title={Cytokine-induced cytokine production by conventional and innate lymphoid cells.},
  author={Liying Guo and Ilkka S Junttila and William E. Paul},
  journal={Trends in immunology},
  year={2012},
  volume={33 12},
  pages={598-606}
}
Innate immune and differentiated T cells produce signature cytokines in response to cytokine stimulation. Optimal production requires stimulation by an NF-κB inducer, most commonly an interleukin (IL)-1 family member, and a STAT activator. Usually, there is linkage between the IL-1 family member, the activated STAT and the cytokines produced: IFNγ producers respond to the IL-1 family member, IL-18 and IL-12, a STAT4 activator; IL-13 producers respond to IL-33 (although for ILC2 cells this may… CONTINUE READING