Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment.

@article{Pollak2002CytokineinducedCI,
  title={Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment.},
  author={Yehuda Pollak and Raz Yirmiya},
  journal={The international journal of neuropsychopharmacology},
  year={2002},
  volume={5 4},
  pages={389-99}
}
Several lines of evidence indicate that cytokine-mediated communication pathways between the immune system and the brain are involved in the pathophysiology of depression: (1) . Depression is highly prevalent in various medical conditions, including infectious, autoimmune and neurodegenerative diseases. This clinical association cannot be attributed solely to psychological distress, and it probably reflects direct activation of illness-induced physiological processes. (2). Experiments in humans… CONTINUE READING

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