Cytokine-induced acute inflammation in the brain and spinal cord.

  title={Cytokine-induced acute inflammation in the brain and spinal cord.},
  author={Lisa Schnell and Sara Fearn and Martin E. Schwab and V Hugh Perry and Daniel C. Anthony},
  journal={Journal of neuropathology and experimental neurology},
  volume={58 3},
Different compartments in the central nervous system mount distinct inflammatory responses. The meninges and choroid plexus respond to pro-inflammatory stimuli in a manner reminiscent of a peripheral inflammatory response, whereas the brain parenchyma is refractory. Trauma-induced lesions in brain and in spinal cord are associated with leukocyte infiltration, blood-brain barrier (BBB) breakdown, and secondary tissue destruction. Unexpectedly, these phenomena are generally more pronounced in the… CONTINUE READING
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