Cytokine imbalance in the pathophysiology of major depressive disorder.

  title={Cytokine imbalance in the pathophysiology of major depressive disorder.},
  author={Yong Ku Kim and K Na and Kyung-ho Shin and Han-Yong Jung and So-Hyun Choi and Jung-Bum Kim},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={31 5},
OBJECTIVE A substantial body of evidence indicates that dysregulation of the immune system is associated with Major Depressive Disorder (MDD). Because most cytokines have pleiotropic effects, we measured various subsets of cytokines to examine the association between immune response and MDD. METHODS Forty-eight hospitalized MDD patients and 63 normal controls were recruited. We measured in vitro monocytic (IL-6 and tumor necrosis factor (TNF)-alpha), Th1 (interferon (IFN)-gamma and… CONTINUE READING
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