Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk.

@article{Cherry2008CytokineGS,
  title={Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk.},
  author={Catherine Louise Cherry and Ann A Rosenow and Jacquita S. Affandi and Justin C. Mcarthur and Steven L. Wesselingh and Patricia Price},
  journal={AIDS research and human retroviruses},
  year={2008},
  volume={24 2},
  pages={117-23}
}
Nucleoside analog-associated sensory neuropathy (NRTI-SN) attributed to stavudine, didanosine, or zalcitabine (the dNRTIs) and distal sensory polyneuropathy (DSP) attributed to HIV are clinically indistinguishable. As inflammatory cytokines are involved in DSP, we addressed a role for inflammation in NRTI-SN by determining the alleles of immune-related genes carried by patients with and without NRTI-SN. Demographic details associated with risk of various neuropathies were included in the… CONTINUE READING