Cytokine generation, promoter activation, and oxidant-independent NF-κB activation in a transfectable human neutrophilic cellular model

@article{Ear2007CytokineGP,
  title={Cytokine generation, promoter activation, and oxidant-independent NF-κB activation in a transfectable human neutrophilic cellular model},
  author={Thornin Ear and Patrick P McDonald},
  journal={BMC Immunology},
  year={2007},
  volume={9},
  pages={14 - 14}
}
Human neutrophils are key players of innate immunity, and influence inflammatory and immune reactions through the production of numerous cytokines and chemokines. Despite major advances in our understanding of this important functional response of neutrophils, the short lifespan of these cells and their resistance to transfection have always been an obstacle to the detailed dissection of signaling pathways and effector responses that is often possible in other cell types. Here, we report that… CONTINUE READING