Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity.

@article{Fakhrai1995CytokineGT,
  title={Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity.},
  author={Habib Fakhrai and Daniel L. Shawler and Ruth A. Gjerset and Robert K. Naviaux and James Koziol and Ivor Royston and Robert E. Sobol},
  journal={Human gene therapy},
  year={1995},
  volume={6 5},
  pages={591-601}
}
We evaluated the effects of different doses of interleukin-2 (IL-2)-transduced fibroblasts in the treatment of colorectal carcinoma in the CT-26 murine tumor model. Immunization with a mixture of irradiated tumor cells and IL-2-transduced fibroblasts (100 units of IL-2/24 hr) induced significantly greater protection against a live tumor challenge compared to irradiated tumor cells alone (22/35, 65% vs. 10/30, 33%, p < 0.02). Protective effects were observed with doses of IL-2-transduced… CONTINUE READING

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