Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.

@article{Vandenbroeck2012CytokineGP,
  title={Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.},
  author={Koen Vandenbroeck},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2012},
  volume={32 4},
  pages={
          139-51
        }
}
Cytokine (receptor) genes have traditionally attracted great interest as plausible genetic risk factors for autoimmune disease. Since 2007, the implementation of genome-wide association studies has facilitated the robust identification of allelic variants in more than 35 cytokine loci as susceptibility factors for a wide variety of over 15 autoimmune disorders. In this review, we catalog the gene loci of interleukin, chemokine, and tumor necrosis factor receptor superfamily and ligands that… CONTINUE READING
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