Cytokine gene polymorphisms and early pregnancy loss

@article{Mashkina2015CytokineGP,
  title={Cytokine gene polymorphisms and early pregnancy loss},
  author={Elena Vladimirovna Mashkina and Konstantin A Kovalenko and N. V. Fomina and Tatyana Pavlovna Shkurat},
  journal={Russian Journal of Genetics: Applied Research},
  year={2015},
  volume={5},
  pages={500-506}
}
A disbalance of pro- and antiinflammatory cytokines can negatively affect the early stages of human embryogenesis. The association between polymorphism of cytokine genes (–31C-T IL1β,–174G-C IL6,–308G-A TNFα, and–592C-A and–819C-T IL10) and pregnancy loss was studied. The analysis was performed on DNA samples from two groups of women with pregnancy loss: those with a missed abortion (MA) (n = 62) and those with a spontaneous abortion (SA) (n = 62). The control group included 114 women with… CONTINUE READING
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