Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland.

@article{Basavaraju2015CytokineGP,
  title={Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland.},
  author={Umesh Basavaraju and Fatma M. Shebl and A. Jay Palmer and Susan Berry and Georgina L Hold and Emad M. El-Omar and Charles S. Rabkin},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={2015},
  volume={24 4},
  pages={296-304}
}
Cytokine gene polymorphisms modify expression and their circulating protein levels reflect inflammatory response. Chronic inflammation plays a key role in the pathogenesis of colorectal neoplasia (CRN) associated with inflammatory bowel disease, but it is not clear whether inflammation is a cause or an effect of tumours in sporadic CRN. We therefore investigated the association of cytokine gene polymorphisms and circulating cytokine levels on the risk of CRN in Northeast Scotland, which has a… CONTINUE READING
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