Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival

@article{Bellone2005CytokineEP,
  title={Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival},
  author={Graziella Bellone and Carlo Smirne and Francesco Angelo Mauri and Elena Tonel and Anna Carbone and Alessandra Buffolino and Luca Dughera and Antonio Robecchi and Mario Pirisi and Giorgio Emanuelli},
  journal={Cancer Immunology, Immunotherapy},
  year={2005},
  volume={55},
  pages={684-698}
}
Cytokine shedding by tumor cells into the local microenvironment modulates host immune response, tumor growth, and metastasis. The study aimed to verify the hypothesis that the immunological microenvironment of pancreatic carcinoma exists in a prevalently immunosuppressive state, influencing survival. We analyzed expression profiles of pro-inflammatory (IL-1β, IL-2, IL-6, IL-8, IL-12 p40, IL-18 and IFN-γ) and anti-inflammatory (IL-10, IL-11, IL-13 and TGF-β isoforms) cytokines. The study was… 

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