Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival

  title={Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival},
  author={G. Bellone and C. Smirne and F. Mauri and E. Tonel and A. Carbone and Alessandra Buffolino and L. Dughera and A. Robecchi and M. Pirisi and G. Emanuelli},
  journal={Cancer Immunology, Immunotherapy},
  • G. Bellone, C. Smirne, +7 authors G. Emanuelli
  • Published 2005
  • Biology, Medicine
  • Cancer Immunology, Immunotherapy
  • Cytokine shedding by tumor cells into the local microenvironment modulates host immune response, tumor growth, and metastasis. The study aimed to verify the hypothesis that the immunological microenvironment of pancreatic carcinoma exists in a prevalently immunosuppressive state, influencing survival. We analyzed expression profiles of pro-inflammatory (IL-1β, IL-2, IL-6, IL-8, IL-12 p40, IL-18 and IFN-γ) and anti-inflammatory (IL-10, IL-11, IL-13 and TGF-β isoforms) cytokines. The study was… CONTINUE READING
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