Cytokine expression in three mouse models of experimental hepatitis.

@article{Sass2002CytokineEI,
  title={Cytokine expression in three mouse models of experimental hepatitis.},
  author={G. Sass and Sonja Heinlein and A. Agli and R. Bang and J. Sch{\"u}mann and G. Tiegs},
  journal={Cytokine},
  year={2002},
  volume={19 3},
  pages={
          115-20
        }
}
The activation of T-cells and macrophages and subsequent induction of cytokines are critical factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, e.g. TNF has been shown to induce liver injury while counter regulation by anti-inflammatory cytokines, e.g. IL-10 is protective. We compared the induction of liver injury and the expression pattern of a variety of cytokines in T-cell- versus non-T-cell-dependent mouse models of liver injury. TNF, IFNgamma, IL-2, IL-4… Expand
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