Cytokine expression in squamous intraepithelial lesions of the uterine cervix: implications for the generation of local immunosuppression.

@article{Giannini1998CytokineEI,
  title={Cytokine expression in squamous intraepithelial lesions of the uterine cervix: implications for the generation of local immunosuppression.},
  author={Sandra L. Giannini and Walid M Al-Saleh and H Piron and Nathalie Jacobs and Jean Doyen and Jacques Boniver and Philippe O Delvenne},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={113 2},
  pages={183-9}
}
We have addressed the notion that the progression of cancer of the uterine cervix is associated with a preferential constraint on the development of a type 1 cellular mediated response, which is necessary to efficiently eliminate (pre)neoplastic cells. Based on the importance of cytokines in the regulation of an appropriate immune response, we have evaluated the expression of IL-12p40, IL-10 and transforming growth factor-beta 1 (TGF-beta1). Using reverse transcriptase-polymerase chain reaction… CONTINUE READING

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Inverse modulation of interleukin-10 and -12 in the blood of women with preneoplastic lesion of the uterine cervix

  • N Jacobs, SL Giannini, J Doyen
  • Clin Exp Immunol
  • 1998

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