Cytokine expression during orthotopic corneal allograft rejection in mice.

@article{Sano1998CytokineED,
  title={Cytokine expression during orthotopic corneal allograft rejection in mice.},
  author={Yoichiro Sano and Hideya Osawa and Chie Sotozono and Shigeru Kinoshita},
  journal={Investigative ophthalmology & visual science},
  year={1998},
  volume={39 10},
  pages={1953-7}
}
PURPOSE The acquisition of cell-mediated immunity against donor antigens has been shown to be associated with rejection of orthotopic corneal allografts, but the mechanisms that cause corneal allograft destruction in grafted tissue remain obscure. To determine which T-cell subsets infiltrate graft tissue and cause graft rejection, cytokine expression was examined in corneal tissue after orthotopic corneal allograft. METHODS BALB/c mice received orthotopic corneal allografts from either… CONTINUE READING

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