Cytokine effects on glutamate uptake by human astrocytes.

  title={Cytokine effects on glutamate uptake by human astrocytes.},
  author={Shuxian Hu and Wen Sheng and Laura C. Ehrlich and Phillip K. Peterson and Chun Cheih Chao},
  volume={7 3},
Glutamate uptake by astrocytes has been postulated to play a neuroprotective role during brain inflammation. Using primary human fetal astrocyte cultures, we investigated the influence of selected cytokines on glutamate uptake activity. Interleukin (IL)-1beta and tumor necrosis factor-alpha dose-dependently inhibited astrocyte glutamate uptake, whereas interferon (IFN)-gamma alone stimulated this activity. The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine, blocked IL-1beta… CONTINUE READING


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