Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

@article{Pace2007CytokineeffectsOG,
  title={Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression},
  author={Thaddeus W. W. Pace and Fang di Hu and Andrew H. Miller},
  journal={Brain, Behavior, and Immunity},
  year={2007},
  volume={21},
  pages={9-19}
}
Glucocorticoids play an essential role in the response to environmental stressors, serving initially to mobilize bodily responses to challenge and ultimately serving to restrain neuroendocrine and immune reactions. A number of diseases including autoimmune, infectious and inflammatory disorders as well as certain neuropsychiatric disorders such as major depression have been associated with decreased responsiveness to glucocorticoids (glucocorticoid resistance), which is believed to be related… CONTINUE READING
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