Cytokine dysregulation as a mechanism of graft versus host disease.

@article{Ferrara1993CytokineDA,
  title={Cytokine dysregulation as a mechanism of graft versus host disease.},
  author={James L. M. Ferrara},
  journal={Current opinion in immunology},
  year={1993},
  volume={5 5},
  pages={
          794-9
        }
}
Graft versus host disease (GVHD) remains the major complication of allogeneic bone marrow transplantation. T cells in the donor bone marrow recognize and react against host alloantigens and thereby initiate GVHD, but the precise mechanisms by which host tissues are damaged remain unclear. Recently, several convergent lines of evidence have suggested that inflammatory cytokines act as mediators of acute GVHD. Most of the clinical manifestations of GVHD may in fact be due to the dysregulated… CONTINUE READING
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