Cytokine-dependent gp 130 Receptor Subunit Regulates Human Fetal Pituitary Adrenocorticotropin Hormone and Growth Hormone Secretion

@inproceedings{Shimon2013CytokinedependentG1,
  title={Cytokine-dependent gp 130 Receptor Subunit Regulates Human Fetal Pituitary Adrenocorticotropin Hormone and Growth Hormone Secretion},
  author={Ilan Shimon and Xinmin Yan and David W Ray and Shlomo Melmed},
  year={2013}
}
We have shown recently that leukemia inhibitory factor (LIF) and oncostatin M (OSM), two members of the gp130dependent cytokine family, stimulate murine proopiomelanocortin (POMC) transcription and adrenocorticotropin hormone (ACTH) secretion. LIF and corticotropin-releasing hormone (CRH) also synergistically induced in vivo ACTH secretion in fetal nonhuman primates. To elucidate the role of the gp130-related cytokines in human pituitary hormone regulation, we tested expression of gp130-related… CONTINUE READING
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