Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.

@article{Jungraithmayr2013CytokineCN,
  title={Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.},
  author={Wolfgang Jungraithmayr and Laura Codarri and Gr{\'e}gory Bouchaud and Carsten Krieg and Onur Boyman and G{\'a}bor Gy{\"u}lv{\'e}szi and Burkhard Becher and Walter Weder and Christian M{\"u}nz},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={187 12},
  pages={1349-59}
}
RATIONALE Natural killer (NK) cells are innate lymphocytes that target virus-infected and tumor cells. Much less is known about their ability to limit adaptive immune responses. OBJECTIVES Thus, we investigated to what extent NK cells can influence mouse lung allograft rejection. METHODS For this purpose, we employed an orthotopic lung transplantation model in mice. MEASUREMENTS AND MAIN RESULTS We demonstrate here that NK cells infiltrate mouse lung allografts before T cells and thereby… CONTINUE READING