Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines.

Abstract

We have developed an in vitro differentiation assay in which human naive CD4(+) cells are driven toward either the Th1 or Th2 phenotype. We have examined the interrelationships among the expression of IL-2, IL-4, IL-5, IL-10, IL-13, GM-CSF, and IFN-gamma in individual cells using intracellular cytokine staining at various times during the differentiation… (More)

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@article{Cousins2002CytokineCD, title={Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines.}, author={David J Cousins and Tak Hoo Lee and Dontcho Z. Staynov}, journal={Journal of immunology}, year={2002}, volume={169 5}, pages={2498-506} }