Cytokine-binding proteins: stimulating antagonists.

@article{Klein1995CytokinebindingPS,
  title={Cytokine-binding proteins: stimulating antagonists.},
  author={Bernard Klein and Herv{\'e} Brailly},
  journal={Immunology today},
  year={1995},
  volume={16 5},
  pages={
          216-20
        }
}
Cytokine-binding proteins (CBPs) block the ability of cytokines to interact with their receptors. These agents can potentially provide a means of treating pathological conditions that have a significant cytokine involvement. However, a major drawback of such approaches relates to the fact that CBPs stabilize the cytokine in the form of a cytokine-CBP complex in vivo. Here, Bernard Klein and Hervé Brailly discuss the possibility that CBPs behave either as agonists or antagonists according to… CONTINUE READING
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