Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.

@article{Ohkawara1997CytokineAE,
  title={Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.},
  author={Yuichi Ohkawara and X F Lei and Martin R. St{\"a}mpfli and Jean S Marshall and Zhou Xing and Manel Jordana},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={16 5},
  pages={510-20}
}
Selective accumulation of eosinophils and activated CD4+ cells is now considered a central event in the pathogenesis of asthma, and this process is thought to be mediated by a number of cytokines including tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), and the Type 2 cytokines interleukin-4 (IL-4) and IL-5. To carry out a detailed time-course analysis of cellular changes in the bronchoalveolar lavage fluid (BAL), peripheral blood (PB), and… CONTINUE READING
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