Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry.

@article{Quan2014CytokineAC,
  title={Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry.},
  author={Lei Quan and Zhihong Gong and Song Yao and Elisa V. Bandera and Gary Robert Zirpoli and Helena Hwang and Michelle R. Roberts and Gregory L. Ciupak and Warren Davis and Lara E. Sucheston and Karen S. Pawlish and Dana Howard Bovbjerg and Lina Jandorf and Citadel J Cabasag and J Coignet and Christine B. Ambrosone and Chi-chen Hong},
  journal={International journal of cancer},
  year={2014},
  volume={134 6},
  pages={1408-21}
}
Disparities in breast cancer biology are evident between American women of African ancestry (AA) and European ancestry (EA) and may be due, in part, to differences in immune function. To assess the potential role of constitutional host immunity on breast carcinogenesis, we tested associations between breast cancer risk and 47 single nucleotide polymorphisms (SNPs) in 26 cytokine-related genes of the adaptive immune system using 650 EA (n = 335 cases) and 864 AA (n = 458 cases) women from the… CONTINUE READING