Cytokine and S100B levels in paediatric patients undergoing corrective cardiac surgery with or without total circulatory arrest.

@article{Ashraf1999CytokineAS,
  title={Cytokine and S100B levels in paediatric patients undergoing corrective cardiac surgery with or without total circulatory arrest.},
  author={S. N. Ashraf and Kallshankar Bhattacharya and Yin Tian and Kevin G. Watterson},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={1999},
  volume={16 1},
  pages={
          32-7
        }
}
OBJECTIVES Neurological damage following cardiopulmonary bypass (CPB) is difficult to objectively evaluate in infants. In adults, serum elevations of astroglial S100B correlate with proven brain injury independent of operative temperature. The deleterious effects of inflammatory cytokines, generated during CPB, on the brain have not been studied in infants using S100B as a marker for cerebral injury. METHODS Twelve neonates, weighing 3.3 +/- 0.2 kg (total circulatory arrest group (TCA)) and… CONTINUE READING
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