Cytokine Reduction in the Treatment of Joint Conditions

Abstract

The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradative enzymes, and by inhibition of… (More)

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Cite this paper

@article{Sipe1994CytokineRI, title={Cytokine Reduction in the Treatment of Joint Conditions}, author={Je. Sipe and Johanne Martel-Pelletier and Ivan G. Otterness and J -P Pelletier}, journal={Mediators of Inflammation}, year={1994}, volume={3}, pages={243 - 256} }