Cytokine Reduction in the Treatment of Joint Conditions


The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradative enzymes, and by inhibition of… (More)


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@article{Sipe1994CytokineRI, title={Cytokine Reduction in the Treatment of Joint Conditions}, author={Je. Sipe and Johanne Martel-Pelletier and Ivan G. Otterness and J -P Pelletier}, journal={Mediators of Inflammation}, year={1994}, volume={3}, pages={243 - 256} }