Cytokine Priming Enables Triggering of Naive Auto-Reactive CD 8 * T Cells by Weak Agonist Ligands of the TCR by

@inproceedings{Dubois2012CytokinePE,
  title={Cytokine Priming Enables Triggering of Naive Auto-Reactive CD 8 * T Cells by Weak Agonist Ligands of the TCR by},
  author={Stephanie L. Dubois},
  year={2012}
}
The activation of naive CD8+ T cells by an antigen requires two different signals. The first signal is mediated via the T cell receptor (TCR) following its interaction with the peptide presented on class-I major histocompability complex (MHC-I) molecules. The second signal is delivered via the co-stimulatory receptors upon recognition of their ligands on antigen presenting cells. However, in response to homeostatic pressure, as in lymphopenia, naive T cells undergo proliferation without… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 222 REFERENCES

Autoimmunity during lymphopenia: a two-hit model.

  • Clinical immunology
  • 2006
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Cellular and genetic mechanisms of self tolerance and autoimmunity

Christopher C. Goodnow, Jonathon Sprent, Barbara Fazekas de St Groth, Carola G. Vinuesa
  • Nature
  • 2005
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

  • The Journal of experimental medicine
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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